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arwiki تقران سفعي; cawiki Queratosi actínica; dewiki Aktinische Keratose; enwiki eswiki Queratosis actínica; fiwiki Aurinkokeratoosi; frwiki Kératose actinique. Title: La keratose actinique au diapason de la photocarcinogenese en champs. Un concept revisite. Language: French. Alternative title: [en] Actinic keratosis in . KERATOSE ACTINIQUE HYPERTROPHIQUE DGNRE. Limites de rsection saines. (Diagnostic diffrenciel: Kerato-acanthome, l’volution n’est pas en faveur).

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Often they will reappear in a few weeks or months, particularly after unprotected sun exposure.

Healing varies from 5—10 days on face, 3—4 weeks on the hands, and 6 weeks or longer on the legs. Results are variable and the course of treatment may need repeating from time to time. As there are multiple effective treatments, patient preference and lifestyle are also factors that physicians consider when determining the management plan for actinic keratosis. This is suspected to be related to the abnormal keratinocyte proliferation and differentiation in AKs, which facilitate an environment for HPV replication.

AK lesions may also come and go– in a cycle of appearing on the skin, remaining for months, and then disappearing. Lesions tumours and cancers, Dermal infiltrative. AK counting has been repeatedly shown to be unreliable, even among expert dermatologists. Actinic keratoses may be treated by a variety of methods freezing, superficial curettage, application of antineoplastic chemotherapeutic agents, and surgical excision.

Asymptomatic flat keratoses may not require active treatment but should be kept under observation. Given the aforementioned differering clinical outcomes, it is difficult to predict the clinical course of any given actinic keratosis.


The surgical wound is sutured stitched.

In severely chronically sun damaged individuals, actnique may also be found on the upper trunk, upper and lower limbs, and dorsum of feet. This condition is termed field cancerization.

Epidemiology of actinic keratoses.

A light freeze for a superficial actinic keratosis usually leaves no mark, but longer freeze times result in hypopigmentation or actiniqye. The lesions are usually asymptomatic, but can be tender, itch, bleed, or produce a stinging or burning sensation.

Physical treatments are used to destroy individual keratoses that are generally symptomatic or have a thick hard surface scale. For more go to Actinic keratosis Ref. Wikiquote 0 entries edit. They are more likely to appear if the immune function is poor, due to ageing, recent sun exposure, predisposing disease or certain drugs. Actinic keratosis is usually easy to diagnose clinically.

Actinic keratoses may qctinique months or years after treatment. Limites de rsection saines Diagnostic diffrenciel: Please help improve this article by adding citations to reliable sources. World Journal of Clinical Oncology.

Dysregulation of the p53 pathway can thus result in keratos replication of dysplastic keratinocytes, thereby serving as a source of neoplastic growth and the development of AK, as well as possible progression from AK to skin cancer. Human Phenotype Ontology release Aphthous stomatitis oral candidiasis lichen planus leukoplakia pemphigus vulgaris mucous membrane pemphigoid cicatricial pemphigoid herpesvirus coxsackievirus syphilis systemic histoplasmosis squamous-cell carcinoma.

A specimen is sent for pathological examination.

Actinic keratosis – Wikipedia

The lesions may recur in time, in which case they may be retreated by the same or a different method. Size commonly ranges between 2 and 6 millimeters in size, but they can grow to be several centimeters in diameter. The number and severity of actinic keratoses can also be reduced by taking nicotinamide vitamin B3 mg twice daily. Clinical Dermatology Sixth ed. Photoaging leads to an accumulation of oncogenic changes, resulting in a proliferation of mutated keratinocytes that can manifest as AKs or other neoplastic growths.


Primary prevention of AKs is achieved by limiting intense sun exposure through sun-protective behaviour, including seeking deep shade, wearing sun-protective clothing and applying sunscreen regularly to exposed skin, from an early age.

Topical retinoids have been studied in the treatment of AK with modest results, and the American Academy of Dermatology does not currently recommend this as a first-line therapy.

Accumulation of p53 protein, presumably as a result of mutation, has been found in almost three fourths of actinic keratosis lesions and found to correlate with the degree of atypia.

Actinic keratoses are usually removed because kerarose are unsightly or uncomfortable, or because of the risk that skin cancer may develop in them.

Actinic keratosis AK is a pre-cancerous [2] area of thick, scaly, or crusty skin. Weedon’s Skin Pathology 3rd ed. This page was last edited on 14 Decemberat Wikibooks 0 entries edit.